Journal article
FOXM1 is lower in human fetal membranes after spontaneous preterm labour and delivery
R Lim, G Barker, M Lappas
Reproduction Fertility and Development | Published : 2014
DOI: 10.1071/RD13140
Abstract
Spontaneous preterm birth is usually associated with infection, inflammation or both. Forkhead box (FOX) M1 (FOXM1), a member of the FOX family of transcription factors, has been associated with inflammation. The aim of this study was to determine whether FOXM1 regulates the expression and release of pro-labour mediators in human gestational tissues. FOXM1 mRNA and protein expression were determined in fetal membranes from women at (1) preterm no labour: Caesarean section with no labour and (2) preterm labour: after spontaneous labour and delivery. Primary amnion cells were utilised to investigate the effect of small interfering RNA (siRNA)-mediated gene silencing of FOXM1 on pro-labour medi..
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Funding Acknowledgements
The following are gratefully acknowledged: Clyde Riley (Department of Obstetrics and Gynaecology, University of Melbourne) for his technical assistance with the immunohistochemistry; research midwives Gabrielle Fleming, Asha Ferguson and Debra Jinks for collection of clinical samples; obstetrics and midwifery staff of the Mercy Hospital for Women for their co-operation. Dr Martha Lappas is the recipient of a National Health and Medical Research Council (NHMRC) Career Development Fellowship (grant no. 1047025). Funding for iMark Microplate Absorbance Reader, Chemi-Doc system and Leica Qwin Image Analysis System was, in part, provided by the Medical Research Foundation for Women and Babies.